Hypoxia and the Circulation - Hardcoverby Stephan Blackwood (Editor) Hypoxia refers to a condition in which the body or some part of the body does not receive enough oxygen supply at the tissue level. It can be categorized as either generalized, where entire body is affected, or localized, where a part of the body is affected. It is a pathological condition including changes in the arterial oxygen concentrations. These types of changes can also occur during normal physiology, such as while